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- 치2-202호
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학력
- 대청중학교 졸업
- 단국대학교 사범대학 부속고등학교 졸업
- 한림대학교 유전공학과(Genetic Engineering) 이학사
- 한림대학교 유전공학과(Genetic Engineering) 이학석사(단백질 생화학 전공(Advisor : Soo Young Choi, Ph.D.))
- 한림대학교 바이오메디컬학과(Biomedical Science) 이학박사(단백질 생화학 전공(Advisor : Soo Young Choi, Ph.D.))
- 한림대학교 의과대학 교육조교, 연구조교
- 한림대학교 생명공학연구소 연구원, 연구교수
- 강릉원주대학교 치과대학 치의학과 생화학교실 교수(현재)
논문 (최근 5년)
2016년
- 01. Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)
- 02. Gambogic acid induces apoptotic cell death in T98G glioma cells. Bioorganic & Medicinal Chemistry Letters (2016)
- 03. Heme Oxygenase-1 Protects Neurons from Ischemic Damage by Upregulating e-x-p-r-e-s-s-i-o-n of Cu,Zn-Superoxide Dismutase, Catalase, and Brain-derived Neurotrophic Factor in the Rabbit Spinal Cord. Neurochemical Research (2016)
- 04. Ischemia-induced changes of PRAS40 and p-PRAS40 immunoreactivities in the gerbil hippocampal CA1 region after transient cerebral ischemia. Cellular and Molecular Neurobiology (2016)
- 05. A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. Scientific Reports (2016)
- 06. Chronic Type 2 Diabetes Reduces the Integrity of the Blood–Brain Barrier by Reducing Tight Junction Proteins in the Hippocampus. Journal of Veterinary Medical Science (2016)
- 07. Tat-ATOX1 inhibits streptozotocin (STZ)-induced pancreatic RINm5F cell death and attenuates diabetes in a mice model. International Journal of Molecular Medicine (2016)
- 08. Tat-NOL3 protects against oxidative stress-induced hippocampal neuronal cell death by regulation of apoptotic pathways. International Journal of Molecular Medicine (2016)
- 09. Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults. Free Radical Biology & Medicine (2016)
- 10. Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia. NEURAL REGENERATION RESEARCH (2016)
- 11. PEP-1-GSTpi protein enhanced hippocampal neuronal cell survival after oxidative damage. BMB Reports (2016)
- 12. Postnatal changes in glucose transporter 3 e-x-p-r-e-s-s-i-o-n in the dentate gyrus of the C57BL/6 mouse model. Laboratory Animal Research (2016)
- 13. Topical delivery of 4-hexylresorcinol promotes wound healing via tumor necrosis factor-a suppression. Burns (2016)
- 14. Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory. Mol Med Rep. (2016)
- 15. Lack of evidence in neurite growth in gerbil hippocampal CA1 region 15 days after transient forebrain ischemia. Animal Cells and Systems (2016)
- 16. Topical delivery of 4-hexylresorcinol promotes wound healing via tumor necrosis factor-α suppression. Burns (2016)
- 17. Protective effects of Tat-NQO1 against oxidative stress-induced HT-22 cell damage, and ischemic injury in animals. BMB Rep. (2016)
- 18. Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway. Molecular Brain (2016)
- 19. Dendropanax morbifera Léveille extract ameliorates cadmium-induced impairment in memory and hippocampal neurogenesis in rats. BMC Complementary and Alternative Medicine (2016)
- 20. Cu,Zn-Superoxide Dismutase Increases the Therapeutic Potential of Adipose-derived Mesenchymal Stem Cells by Maintaining Antioxidant Enzyme Levels. Neurochem Res. (2016)
- 21. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. (2016)
- 22. Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils. Neural Regen Res. (2016)
2017년
- 23. Accelerated biodegradation of silk sutures through matrix metalloproteinase activation by incorporating 4-hexylresorcinol. Scientific Reports (2017)
- 24. Temporal and spatial changes of monocarboxylate transporter 4 e-x-p-r-e-s-s-i-o-n in the hippocampal CA1 region following transient forebrain ischemia in the Mongolian gerbil. MOLECULAR MEDICINE REPORTS (2017)
- 25. SUMO-1 delays neuronal damage in the spinal cord following ischemia/reperfusion. MOLECULAR MEDICINE REPORTS (2017)
- 26. Age-associated alterations in constitutively expressed cyclooxygenase-2 immunoreactivity and protein levels in the hippocampus. MOLECULAR MEDICINE REPORTS (2017)
- 27. Effects of long-term post-ischemic treadmill exercise on gliosis in the aged gerbil hippocampus induced by transient cerebral ischemia. Molecular Medicine Reports (2017)
- 28. Chronic administration of SUMO-1 has negative effects on novel object recognition memory as well as cell proliferation and neuroblast differentiation in the mouse dentate gyrus. MOLECULAR MEDICINE REPORTS (2017)
- 29. In vivo bone regeneration ability of different layers of natural silk cocoon processed using an eco-friendly method. Macromolecular Research (2017)
- 30. Effects of PEP-1-FK506BP on cyst formation in polycystic kidney disease. BMB Rep. (2017)
- 31. Tat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord. Cell Death and Disease (2017)
- 32. Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension. Free Radical Biology and Medicine (2017)
- 33. CD74-immunoreactive activated M1 microglia are shown late in the gerbil hippocampal CA1 region following transient cerebral ischemia. MOLECULAR MEDICINE REPORTS (2017)
- 34. Proteomic approach to detect changes in hippocampal protein levels in an animal model of type 2 diabetes. Neurochemistry International (2017)
- 35. Neuroprotection of ischemic preconditioning is mediated by thioredoxin 2 in the hippocampal CA1 region following a subsequent transient cerebral ischemia. Brain Pathology (2017)
- 36. Hydroquinone strongly alleviates focal ischemic brain injury via blockage of blood-brain barrier disruption in rats. Toxicological Sciences (2017)
- 37. Gambogic Acid-induced Autophagy and the MAPK Pathway in T98G Glioblastoma Cells. BULLETIN OF THE KOREAN CHEMICAL SOCIETY (2017)
- 38. Bone regeneration is associated with the concentration of tumour necrosis factor-α induced by sericin released from a silk mat. Scientific Reports (2017)
- 39. Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis. Data Brief. (2017)
- 40. Roles of HIF-1α, VEGF and NF-κB in ischemic preconditioning-mediated neuroprotection of hippocampal CA1 pyramidal neurons against a subsequent transient cerebral ischemia. Molecular Neurobiology (2017)
2018년
- 41. Effects of chronic scopolamine treatment on cognitive impairment and neurofilament e-x-p-r-e-s-s-i-o-n in the mouse hippocampus. Molecular Medicine Reports (2018)
- 42. Peroxyredoxin-2: A Novel regulator of iron homeostasis in ineffective erythropoiesis. Antioxidants and Redox Signaling (2018)
- 43. Dendropanax morbifera Léveille extract ameliorates D-galactose-induced memory deficits by decreasing inflammatory responses in the hippocampus. Lab Anim Res. (2018)
- 44. Rufinamide, an antiepileptic drug, improves cognition and increases neurogenesis in the aged gerbil hippocampal dentate gyrus via increasing e-x-p-r-e-s-s-i-o-ns of IGF-1, IGF-1R and p-CREB. Chem Biol Interact. (2018)
- 45. Age-dependent changes in vesicular glutamate transporter 1 and 2 e-x-p-r-e-s-s-i-o-n in the gerbil hippocampus. Mol Med Rep. (2018)
- 46. Hypothyroidism increases cyclooxygenase-2 levels and pro-inflammatory response and decreases cell proliferation and neuroblast differentiation in the hippocampus. Mol Med Rep. (2018)
- 47. Age‑dependent alteration in the e-x-p-r-e-s-s-i-o-n of oligodendrocyte‑specific protein in the gerbil hippocampus. Mol Med Rep. (2018)
- 48. Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway. Biochimica et Biophysica Acta (BBA) - General Subjects (2018)
- 49. Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice. Neurochem Res. (2018)
- 50. PEP-1-glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways. Mol Med Rep. (2018)
- 51. Decrease in glucose transporter 1 levels and translocation of glucose transporter 3 in the dentate gyrus of C57BL/6 mice and gerbils with aging. Lab Anim Res. (2018)
- 52. Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model. BMB Rep. (2018)
- 53. Phosphatidylethanolamine-binding protein 1 protects CA1 neurons against ischemic damage via ERK-CREB signaling in Mongolian gerbils. Neurochemistry International (2018)
- 54. PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models. Immunobiology (2018)
- 55. Melatonin improves cognitive deficits via restoration of cholinergic degeneration in a mouse model of scopolamine-induced amnesia. ACS Chemical Neuroscience (2018)
- 56. Dendropanax morbifera Léveille extract ameliorates cesium-induced inflammation in the kidney and decreases antioxidant enzyme levels in the hippocampus. Mol Cell Toxicol (2018)
- 57. Effects of silk solution against laminectomy-induced dural adhesion formation and inflammation in a rat model. J Neurosurg Spine (2018)
- 58. Angioplasty Using 4-Hexylresorcinol-Incorporated Silk Vascular Patch in Rat Carotid Defect Model. Appl. Sci. (2018)
- 59. Tat-ATOX1 inhibits inflammatory responses via regulation of MAPK and NF-B pathways. BMB Rep. (2018)
2019년
- 60. Neuroprotective effects of Tat-ATOX1 protein against MPP+-induced SH-SY5Y cell deaths and in MPTP-induced mouse model of Parkinson’s disease. Biochimie (2019)
- 61. Pretreated fucoidan confers neuroprotection against transient global cerebral ischemic injury in the gerbil hippocampal CA1 area via reducing of glial cell activation and oxidative stress. Biomed Pharmacother (2019)
- 62. Protein disulfide-isomerase A3 significantly reduces ischemia-induced damage by reducing oxidative and endoplasmic reticulum stress. Neurochem Int. (2019)
- 63. 4-Hexylresorcinol and silk sericin increase the e-x-p-r-e-s-s-i-o-n of vascular endothelial growth factor via different pathways. Scientific Reports (2019)
- 64. Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the MAPK and apoptotic signaling pathways. Free Radical Biology and Medicine (2019)
- 65. Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils. International Journal of Molecular Sciences (2019)
- 66. Fate of Astrocytes in The Gerbil Hippocampus After Transient Global Cerebral Ischemia. International Journal of Molecular Sciences (2019)
- 67. Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus. Biomedicine & Pharmacotherapy (2019)
- 68. Chronic high-fat diet-induced obesity in gerbils increases pro-inflammatory cytokines and mTOR activation, and elicits neuronal death in the striatum following brief transient ischemia. Neurochemistry International (2019)
- 69. Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes. Lab Anim Res. (2019)
- 70. Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus. Lab Anim Res. (2019)
- 71. Postnatal changes in constitutive cyclooxygenase-2 e-x-p-r-e-s-s-i-o-n in the mice hippocampus and its function in synaptic plasticity. MOLECULAR MEDICINE REPORTS (2019)
- 72. Phosphoglycerate Mutase 1 Promotes Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus by Facilitating the Phosphorylation of cAMP Response Element-Binding Protein. Neurochemical Research (2019)
- 73. Ginsenoside Rb2 suppresses the glutamate-mediated oxidative stress and neuronal cell death in HT22 cells. J Ginseng Res. (2019)
- 74. Effects of long-term exposure to aluminum in the hippocampus in the type 2 diabetes model rats. Toxicol Res. (2019)
- 75. Oenanthe Javanica Extract Protects Mouse Skin from UVB Radiation via Attenuating Collagen Disruption and Inflammation. Int J Mol Sci. (2019)
- 76. Fluoro-Jade B histofluorescence staining detects dentate granule cell death after repeated five-minute transient global cerebral ischemia. Metabolic Brain Diseases (2019)
- 77. Leaf extracts from Dendropanax morbifera Léveille mitigate mercury-induced reduction of spatial memory, as well as cell proliferation, and neuroblast differentiation in rat dentate gyrus. BMC Complement Altern Med. (2019)
- 78. Tat-HSP70 protects neurons from oxidative damage in the NSC34 cells and ischemic damage in the ventral horn of rabbit spinal cord. Neurochemistry International (2019)
- 79. Melatonin alleviates asphyxial cardiac arrest-induced cerebellar Purkinje cell death by attenuation of oxidative stress. Experimental Neurology (2019)
- 80. Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress. Int J Mol Sci. (2019)
- 81. e-x-p-r-e-s-s-i-o-n changes of CX3CL1 and CX3CR1 proteins in the hippocampal CA1 field of the gerbil following transient global cerebral ischemia. Int J Mol Med. (2019)
- 82. Down-regulation of cyclin-dependent kinase 5 attenuates p53-dependent apoptosis of hippocampal CA1 pyramidal neurons following transient cerebral ischemia. Scientific Reports (2019)
- 83. Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus. Brain Behav. (2019)
- 84. Improved HCN channels in pyramidal neurons and their new e-x-p-r-e-s-s-i-o-n levels in pericytes and astrocytes in the gerbil hippocampal CA1 subfield following transient ischemia. International Journal of Molecular Medicine (2019)
- 85. A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation. Cells (2019)
- 86. Effects of Dendropanax morbifera Léveille extract on hypothyroidism-induced oxidative stress in the rat hippocampus. Food Sci Biotechnol. (2019)
- 87. The effects of proteins released from silk mat layers on macrophages. Maxillofac Plast Reconstr Surg. (2019)
- 88. Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced Damage. Exp Neurobiol. (2019)
- 89. Phosphatidylethanolamine-Binding Protein 1 Ameliorates Ischemia-Induced Inflammation and Neuronal Damage in the Rabbit Spinal Cord. Cells (2019)
- 90. Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus. Laboratory Animal Research (2019)
- 91. Role of pyridoxine in GABA synthesis and degradation in the hippocampus. Tissue and Cell (2019)
- 92. Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages. BMB Rep. (2019)
2020년
- 93. Phosphoglycerate mutase 1 reduces neuronal damage in the hippocampus following ischemia/reperfusion through the facilitation of energy utilization. Neurochemistry International (2020)
- 94. Altered Nurr1 protein e-x-p-r-e-s-s-i-o-n in the hippocampal CA1 region following transient global cerebral ischemia. Molecular Medicine (2020)
- 95. Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by damphetamine. Food and Chemical Toxicology (2020)
- 96. Differential roles of exogenous protein disulfide isomerase A3 on proliferating cell and neuroblast numbers in the normal and ischemic gerbils. Brain Behav. (2020)
- 97. RbAp48 e-x-p-r-e-s-s-i-o-n and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia. Laboratory Animal Research (2020)
- 98. Effects of regional body temperature variation during asphyxial cardiac arrest on mortality and brain damage in a rat model. J Therm Biol. (2020)
- 99. The Administration of 4-Hexylresorcinol Accelerates Orthodontic Tooth Movement and Increases the e-x-p-r-e-s-s-i-o-n Level of Bone Turnover Markers in Ovariectomized Rats. Int. J. Mol. Sci. (2020)
- 100. Post-treatment with oxcarbazepine confers potent neuroprotection against transient global cerebral ischemic injury by activating Nrf2 defense pathway. Biomed Pharmacother. (2020)
- 101. PEP-1-GLRX1 protein exhibits anti-inflammatory effects by inhibiting the activation of MAPK and NF-B pathways in Raw 264.7 cells. BMB Rep. (2020)
- 102. 4-Hexylresorcinol Exhibits Dierent Characteristics to Estrogen. Appl. Sci. (2020)
- 103. Synthesis and biological evaluation of isoliquiritigenin derivatives as a neuroprotective agent against glutamate mediated neurotoxicity in HT22 cells. Bioorganic & Medicinal Chemistry Letters (2020)
- 104. Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling. International Journal of Molecular Sciences (2020)
- 105. Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils. Mar. Drugs (2020)
- 106. Effects of Pyridoxine Deficiency on Hippocampal Function and Its Possible Association with V-Type Proton ATPase Subunit B2 and Heat Shock Cognate Protein 70. Cells (2020)
- 107. Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol Is Mediated by Transforming Growth Factor-1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals. Int. J. Mol. Sci. (2020)
- 108. Cuprizone Affects Hypothermia-Induced Neuroprotection and Enhanced Neuroblast Differentiation in the Gerbil Hippocampus After Ischemia. Cells (2020)
- 109. Laminarin Attenuates Ultraviolet-Induced Skin Damage by Reducing Superoxide Anion Levels and Increasing Endogenous Antioxidants in the Dorsal Skin of Mice. Mar Drugs (2020)
- 110. Changes of fat-mass and obesity-associated protein e-x-p-r-e-s-s-i-o-n in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging. Lab Anim Res. (2020)
- 111. Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase. Redox Biology (2020)
- 112. Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3η. Cells (2020)
- 113. Pyridoxine Deficiency Exacerbates Neuronal Damage after Ischemia by Increasing Oxidative Stress and Reduces Proliferating Cells and Neuroblasts in the Gerbil Hippocampus. Int. J. Mol. Sci. (2020)
- 114. Experimental Pretreatment with Chlorogenic Acid Prevents Transient Ischemia-Induced Cognitive Decline and Neuronal Damage in the Hippocampus through Anti-Oxidative and Anti-Inflammatory Effects. Molecules (2020)
- 115. 4-Hexylresorcinol Administration Increases Dental Hard Tissue Formation and Incisor Eruption Rate in Rats. Appl. Sci. (2020)
- 116. Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines. Molecules (2020)
- 117. Pycnogenol® Supplementation Attenuates Memory Deficits and Protects Hippocampal CA1 Pyramidal Neurons via Antioxidative Role in a Gerbil Model of Transient Forebrain Ischemia. Nutrients (2020)
- 118. Inhibitory effects of 4-hexylresorcinol on root resorption induced by orthodontic tooth movement. Applied Sciences (2020)
- 119. Different level of tumor necrosis factor-a e-x-p-r-e-s-s-i-o-n after administration of silk sericin fraction in RAW264.7 cells. Int. J. Indust. Entomol. (2020)
- 120. Phosphoglycerate Mutase 1 Prevents Neuronal Death from Ischemic Damage by Reducing Neuroinflammation in the Rabbit Spinal Cord. Int. J. Mol. Sci. (2020)
- 121. Synthesis and biological evaluation of chalcone derivatives as neuroprotective agents against glutamate-induced HT22 mouse hippocampal neuronal cell death. Bioorganic & Medicinal Chemistry Letters (2020)
- 122. Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase. Redox Biology (2020)
- 123. Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury. BMB Rep. (2020)
- 124. P27 Protects Neurons from Ischemic Damage by Suppressing Oxidative Stress and Increasing Autophagy in the Hippocampus. Int. J. Mol. Sci. (2020)
- 125. 4-hexylresorcinol-induced protein e-x-p-r-e-s-s-i-o-n changes in human umbilical cord vein endothelial cells as determined by immunoprecipitation high-performance liquid chromatography. PLoS ONE (2020)
- 126. Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment. Mar. Drugs (2020)
- 127. Entacapone Treatment Modulates Hippocampal Proteins Related to Synaptic Vehicle Trafficking. Cells (2020)
- 128. Entacapone promotes hippocampal neurogenesis in mice. Neural Regen Res. (2020)
- 129. Tat-Aldose reductase prevents dopaminergic neuronal cell death by the inhibition of oxidative stress and MAPK activation. International Journal of Molecular Medicine (2020)
- 130. Neuronal death in the CNS autonomic control center comes very early after cardiac arrest and is not significantly attenuated by prompt hypothermic treatment in rats. Cells (2020)
2021년
- 131. Gynura procumbens root extract ameliorates ischemia-induced neuronal damage in the hippocampal CA1 region by reducing neuroinflammation. Nutrients (2021)
- 132. Increased calbindin D28k e-x-p-r-e-s-s-i-o-n by long-term alternate-day fasting does not protect against ischemia-reperfusion injury: spotlight on delayed neuronal death, gliosis and IgG leakage. Int. J. Mol. Sci. (2021)
- 133. CD200 change is involved in neuronal death in gerbil hippocampal CA1 filed following transient forebrain ischemia and postischemic treatment with risperidone displays neuroprotection without CD200 change. International Journal of Molecular Medicine (2021)
- 134. Tyrosine phosphorylation modulates peroxiredoxin-2 activity in normal and diseased red cells. Antioxidants (2021)
- 135. Experimental pretreatment with YES-10® (plant extract rich in scutellarin and chlorogenic acid) protects hippocampal neurons from ischemia/reperfusion injury via antioxidant role. EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)
- 136. Tat-Endophilin A1 Fusion Protein Protects Neurons from Ischemic Damage in the Gerbil Hippocampus: A Possible Mechanism of Lipid Peroxidation Mitigation and Synaptic Plasticity. Cells (2021)
- 137. Increased Calbindin D28k e-x-p-r-e-s-s-i-o-n via Long-Term Alternate-Day Fasting Does Not Protect against Ischemia-Reperfusion Injury: A Focus on Delayed Neuronal Death, Gliosis and Immunoglobulin G Leakage. Int. J. Mol. Sci. (2021)
- 138. Transient forebrain ischemia under hyperthermic condition accelerates memory impairment and neuronal death in the gerbil hippocampus by increasing NMDAR1 e-x-p-r-e-s-s-i-o-n. Molecular Medicine Reports (2021)
- 139. Therapeutic Effects of Decursin and Angelica gigas Nakai Root Extract in Gerbil Brain after Transient Ischemia via Protecting BBB Leakage and Astrocyte Endfeet Damage. Molecules (2021)
- 140. Ischemia-Reperfusion under Hyperthermia Increases Heme Oxygenase-1 in Pyramidal Neurons and Astrocytes with Accelerating Neuronal Loss in Gerbil Hippocampus. Int. J. Mol. Sci. (2021)
- 141. Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway. Biomol Ther. (2021)
- 142. Comparison of age‐dependent alterations in thioredoxin 2 and thioredoxin reductase 2 e-x-p-r-e-s-s-i-o-ns in hippocampi between mice and rats. Laboratory Animal Research (2021)
- 143. 4-Hexylresorcinol Inhibits Class I Histone Deacetylases in Human Umbilical Cord Endothelial Cells. Appl. Sci. (2021)
- 144. Alleviation of Oxidative Stress in Dental Pulp Cells Following 4-Hexylresorcinol Administration in a Rat Model. Appl. Sci. (2021)
- 145. Neuroprotective Effects of Salicin in a Gerbil Model of Transient Forebrain Ischemia by Attenuating Oxidative Stress and Activating PI3K/Akt/GSK3β Pathway. Antioxidants(2021)
- 146. PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson’s Disease. Molecules(2021)
- 147. Cissus verticillata Extract Decreases Neuronal Damage Induced by Oxidative Stress in HT22 Cells and Ischemia in Gerbils by Reducing the Inflammation and Phosphorylation of MAPKs. Plants(2021)
- 148. Transduced Tat-PRAS40 prevents dopaminergic neuronal cell death through ROS inhibition and interaction with 14-3-3σ protein. Free Radical Biology and Medicine(2021)
- 149. Differences in TNF‑α and TNF‑R1 e-x-p-r-e-s-s-i-o-n in damaged neurons and activated astrocytes of the hippocampal CA1 region between young and adult gerbils following transient forebrain ischemia. MOLECULAR MEDICINE REPORTS(2021)
- 150. Changes in Cyclin D1, cdk4, and Their Associated Molecules in Ischemic Pyramidal Neurons in Gerbil Hippocampus after Transient Ischemia and Neuroprotective Effects of Ischemic Preconditioning by Keeping the Molecules in the Ischemic Neurons. Biology(2021)
- 151. Neuroprotective and Anti-Inflammatory Effects of Pinus densiflora Bark Extract in Gerbil Hippocampus Following Transient Forebrain Ischemia. Molecules(2021)
- 152. Neuroprotective effects of 2-heptyl-3-hydroxy-4-quinolone in HT22 mouse hippocampal neuronal cells. Bioorg. Med. Chem. Lett.(2021)
- 153. Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats. Int. J. Mol. Sci.(2021)
- 154. Tat‑p27 Ameliorates Neuronal Damage Reducing α‑Synuclein and Infammatory Responses in Motor Neurons After Spinal Cord Ischemia. Neurochemical Research(2021)
- 155. Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice. Plants(2021)
- 156. Spatial and temporal changes in the PGE2 EP2 receptor in mice hippocampi during postnatal development and its relationship with cyclooxygenase-2. Iran J Basic Med Sci(2021)
- 157. Populus tomentiglandulosa Extract Is Rich in Polyphenols and Protects Neurons, Astrocytes, and the Blood-Brain Barrier in Gerbil Striatum Following Ischemia-Reperfusion Injury. Molecules(2021)
- 158. Silk sericin application increases bone morphogenic protein-2/4 e-x-p-r-e-s-s-i-o-n via a toll-like receptor-mediated pathway. International Journal of Biological Macromolecules(2021)
- 159. Comparison of Neuronal Death, Blood–Brain Barrier Leakage and Infammatory Cytokine e-x-p-r-e-s-s-i-o-n in the Hippocampal CA1 Region Following Mild and Severe Transient Forebrain Ischemia in Gerbils. Neurochemical Research(2021)
- 160. Tat-CIAPIN1 protein prevents against cytokine-induced cytotoxicity in pancreatic RINm5F β-cells. BMB Rep.(2021)
- 161. Increased e-x-p-r-e-s-s-i-o-n of TGF-β1 by 4-hexylresorcinol Is Mediated by Endoplasmic Reticulum and Mitochondrial Stress in Human Umbilical Endothelial Vein Cells Jwa-Young Kim, Dae-Won Kim, Suk Keun Lee, Je-Yong Choi, Xiangguo Che, Seong-Gon Kim, Umberto Garagiola. Appl. Sci.(2021)
- 162. Tat‑thioredoxin 1 reduces inflammation by inhibiting pro‑inflammatory cytokines and modulating MAPK signaling. EXPERIMENTAL AND THERAPEUTIC MEDICINE(2021)
- 163. Utilization of an Intracellular Calcium Mobilization Assay for the Screening of Transduced FK506-Binding Proteins. ASSAY and Drug Development Technologies(2021)
- 164. Therapeutic Effects of Risperidone against Spinal Cord Injury in a Rat Model of Asphyxial Cardiac Arrest: A Focus on Body Temperature, Paraplegia, Motor Neuron Damage, and Neuroinflammation. Vet. Sci.(2021)
- 165. The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells. Maxillofacial Plastic and Reconstructive Surgery(2021)
- 166. Changes in the e-x-p-r-e-s-s-i-o-n of the B subunit of vacuolar H+-ATPase, in the hippocampus, following transient forebrain ischemia in gerbils. Iran J Basic Med Sci(2021)
- 167. Ischemia-Induced Cognitive Impairment Is Improved via Remyelination and Restoration of Synaptic Density in the Hippocampus after Treatment with COG-Up® in a Gerbil Model of Ischemic Stroke. Veterinary Sciences(2021)
특허
- 1. 빌리버딘 환원효소 A 융합단백질을 함유하는 피부염증 치료용 약학 조성물
출원번호: 10-2013-0137333
- 2. 세포투과성 파라옥소네이즈 Ⅰ 융합단백질을 포함하는 항염증 약학 조성물
출원번호: 10-2013-0145391
- 3. 세포투과성 SAG 융합단백질을 포함하는 파킨슨병 치료용 약학 조성물
출원번호: 10-2013-0145388
- 4. 세포침투성 카보닐기 환원효소 융합단백질
출원번호: 10-2013-0157068
- 5. 세포투과성 Atox1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2013-0159413
- 6. 세포투과성 헴 옥시게네이즈 융합단백질을 포함하는 파킨슨병 치료용 약학 조성물
출원번호: 10-2014-0004983
- 7. 세포투과성 SIRT2 융합단백질을 포함하는 당뇨병 치료용 약학 조성물
출원번호: 10-2014-0007570
- 8. 퍼옥시레독신 2 융합단백질을 포함하는 당뇨병 예방 및 치료용 조성물
출원번호: 10-2014-0015225
- 9. SIRT2 융합단백질을 함유하는 관절염 예방 및 치료용 약학 조성물
출원번호: 10-2014-0016451
- 10. PRAS40 융합단백질을 함유하는 다낭신 예방 및 치료용 약학 조성물
출원번호: 10-2014-0022344
- 11. 세포투과성 PRAS40 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2014-0028817
- 12. PON1 융합단백질을 포함하는 파킨슨병 예방 및 치료용 약학 조성물
출원번호: 10-2014-0037927
- 13. 세포투과성 PIM2 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2014-0047324
- 14. 세포투과성 NOL3 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2014-0047807
- 15. 세포투과성 카보닐기 환원효소 융합단백질을 포함하는 항염증 약학 조성물
출원번호: 10-2014-0053965
- 16. 세포투과성 카보닐기 환원효소 융합단백질 및 포졸란을 포함하는 항노화 기능성 화장료 조성물
출원번호: 10-2014-0060339
- 17. 세포투과성 GSTpi 융합단백질을 포함하는 뇌허혈 치료용 약학조성물
출원번호: 10-2014-0077866
- 18. 카탈라제 융합단백질을 포함하는 파킨슨병 예방 및 치료용 약학 조성물
출원번호: 10-2014-0078312
- 19. GADD45a 융합단백질을 포함하는 피부암 예방 및 치료용 약학 조성물
출원번호: 10-2014-0091711
- 20. PEA15 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2014-0134859
- 21. 글루타레독신 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2014-0139524
- 22. 세포투과성 Atox1 융합단백질을 함유하는 다낭신 예방 및 치료용 약학 조성물
출원번호: 10-2015-0004031
- 23. PEA15 융합단백질을 포함하는 항염증 약학 조성물
출원번호: 10-2015-0033207
- 24. 세포투과성 ATOX1 융합단백질을 포함하는 당뇨병 예방 및 치료용 약학 조성물
출원번호: 10-2015-0044854
- 25. 세포투과성 DJ-1 융합단백질을 포함하는 당뇨병 예방 및 치료용 약학 조성물
출원번호: 10-2015-0070726
- 26. 글루타레독신 1 융합단백질을 함유하는 관절염 예방 및 치료용 약학 조성물
출원번호: 10-2015-0070951
- 27. 세포투과성 NQO1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2015-0089570
- 28. 세포투과성 열충격단백질 22 융합단백질을 포함하는 뇌허혈 예방 및 치료용 약학 조성물
출원번호: 10-2015-0111561
- 29. 세포투과성 PRAS40 융합단백질을 포함하는 파킨슨병 예방 및 치료용 약학 조성물
출원번호: 10-2015-0126036
- 30. 세포투과성 ATOX1 융합단백질을 포함하는 파킨슨병 예방 및 치료용 약학 조성물
출원번호: 10-2015-0126033
- 31. 세포투과성 PIM2 융합단백질을 포함하는 파킨슨병 예방 및 치료용 약학 조성물
출원번호: 10-2015-0131419
- 32. 알도즈 환원효소 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2015-0158767
- 33. IDO1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2015-0162183
- 34. 세포투과성 Atox1 융합단백질을 포함하는 치수세포 항염증 약학 조성물
출원번호: 10-2015-0168865
- 35. 빌리버딘 환원효소 A 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2016-0000364
- 36. 사이토카인 유도 세포자기사멸 저해제 1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2016-0049774
- 37. 실크 피브로인을 포함하는 척추 유착방지제
출원번호: 10-2016-0051884
- 38. PEA15 융합단백질을 함유하는 관절염 예방 및 치료용 약학 조성물
출원번호: 10-2016-0060729
- 39. TXNL1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2016-0082193
- 40. 미소막 간격체 및 미소막 간격체-유착방지제 혼합물
출원번호: 10-2016-0098350
- 41. 세포투과성 Atox1 융합단백질을 포함하는 항염증 약학 조성물
출원번호: 10-2016-0106060
- 42. 포졸란을 포함하는 면역증강용 사료 조성물
출원번호: 10-2017-0005264
- 43. 글루타레독신 1 융합단백질을 포함하는 피부 염증 치료용 약학 조성물
출원번호: 10-2017-0020790
- 44. 사이토카인 유도 세포자기사멸 저해제 1 융합단백질을 포함하는 항염증 약학 조성물
출원번호: 10-2017-0021996
- 45. PIN1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2017-0054237
- 46. 세포투과성 PDIA3 융합단백질을 포함하는 파킨슨병 예방 및 치료용 약학 조성물
출원번호: 10-2017-0056150
- 47. PHB1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2017-0057234
- 48. 세포투과성 알도즈 환원효소 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
출원번호: 10-2017-0060255
- 49. 실크 피브로인을 포함하는 복부 유착방지제
출원번호: 10-2017-0072380
- 50. 포졸란, 소목 추출물 및 희첨 추출물을 함유하는 탈모방지 및 발모촉진용 조성물
출원번호: 10-2017-0083224
- 51. 사이클로필린 A 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2017-0125307
- 52. 사이토카인 유도 세포자기사멸 저해제 1 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
출원번호: 10-2017-0125316
- 53. 티오레독신 1 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
출원번호: 10-2017-0126720
- 54. 티오레독신 1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2017-0126723
- 55. RAN 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2017-0129296
- 56. 글루타레독신 1 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
출원번호: 10-2018-0031237
- 57. GSTA2 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2018-0033591
- 58. GSTA2 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
출원번호: 10-2018-0037884
- 59. 실크 피브로인을 포함하는 인공 신경도관
출원번호: 10-2018-0045976
- 60. TXNL1 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
출원번호: 10-2018-0046665
- 61. 빌리버딘 환원효소 A 융합단백질을 포함하는 파킨슨병 예방 또는 치료용 약학 조성물
출원번호: 10-2018-0050975
- 62. PEP-1 및 FKBP를 포함하는 융합 단백질 및 이의 용도
출원번호: 10-2018-0160621
- 63. 실크 피브로인을 포함하는 뼈 또는 치아 재생용 조성물 및 실크 피브로인을 이용한 뼈 또는 치아 재생방법
출원번호: 10-2019-0028512
- 64. 세포 침투성 펩타이드, 이를 포함하는 융합 화합물 및 이 융합 화합물을 포함하는 약학 조성물
출원번호: 10-2019-0065359
- 65. 포스포글리세레이트 뮤테이즈 1 융합단백질 및 이를 포함하는 약학 조성물
출원번호: 10-2019-0068387
- 66. 세포 투과성 HSP70 융합단백질을 포함하는 신경질환 예방 및 치료용 약학 조성물
출원번호: 10-2019-0072341
- 67. 세포 투과성 HSP70 융합단백질을 포함하는 신경 재생용 약학 조성물
출원번호: 10-2019-0078098
- 68. 포스포글리세레이트 뮤테이즈 1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2019-0078845
- 69. 세포 투과성 PGAM1 융합단백질을 포함하는 신경질환 예방 및 치료용 약학 조성물
출원번호: 10-2019-0083255
- 70. 세포투과성 CNRIP1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2019-0089938
- 71. 세포투과성 p27 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2019-0095310
- 72. 세포 투과성 TAGLN3 융합단백질을 포함하는 신경질환 예방 또는 치료용 약학 조성
출원번호: 10-2019-0094829
- 73. 세포 투과성 엔도필린-A1 융합단백질을 포함하는 신경질환 예방 또는 치료용 약학 조성물
출원번호: 10-2019-0095843
- 74. 세포 투과성 p27 융합단백질을 포함하는 신경질환 예방 또는 치료용 약학 조성물
출원번호: 10-2019-0096450
- 75. 세포 투과성 CNRIP1 융합단백질을 포함하는 신경질환 예방 또는 치료용 약학 조성물
출원번호: 10-2019-0099575
- 76. 천연 포졸란을 포함하는 사료 첨가제 조성물
출원번호: 10-2019-0111973
- 77. 세포 투과성 엔도필린-A1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2020-0029511
- 78. 세포 투과성 TAGLN3 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2020-0029640
- 79. 포졸란과 실크 피브로인을 포함하는 뼈 재생용 조성물
출원번호: 10-2020-0034900
- 80. 세포 침투성 펩타이드와 FKBP12를 포함하는 융합 단백질 및 이의 용도
출원번호: 10-2020-0047829
- 81. 새로운 단백질 수송 도메인, 이를 포함하는 융합 화합물 및 이 융합 화합물을 포함하는 약학 조성물
출원번호: 10-2020-0056941
- 82. 티오레독신 1 융합단백질을 포함하는 항염증 약학 조성물
출원번호: 10-2020-0060266
- 83. 세포 투과성 GAPDH 융합단백질을 포함하는 신경질환 예방 또는 치료용 약학 조성물
출원번호: 10-2020-0071984
- 84. 세포 투과성 CRYM 융합단백질을 포함하는 운동신경 질환 예방 또는 치료용 약학 조성물
출원번호: 10-2020-0076925
- 85. 세포 투과성 PGAM5 융합단백질을 포함하는 운동신경 질환 예방 또는 치료용 약학 조성물
출원번호: 10-2020-0080719
- 86. 천연 포졸란을 포함하는 페인트 첨가용 조성물 및 이를 포함하는 페인트 조성물
출원번호: 10-2020-0115161
- 87. 단백질 수송 도메인, 이를 포함하는 융합 화합물 및 이 융합 화합물을 포함하는 약학 조성물
출원번호: 10-2020-0126601
- 88. 세포 투과성 HSPE1 융합단백질을 포함하는 운동신경 질환 예방 또는 치료용 약학 조성물
출원번호: 10-2020-0148582
- 89. PROTEIN TRANSDUCTION DOMAIN, FUSION COMPOUND CONTAINING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE FUSION COMPOUND
출원번호: 17/086031(미국특허출원)
- 90. 세포 투과성 HSPE1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2020-0185715
- 91. 세포 투과성 GAPDH 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2021-0000199
- 92. 세포 투과성 CRYM 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2021-0048150
- 93. 사이토카인 유도 세포자기사멸 저해제 1 융합단백질을 포함하는 당뇨병 예방 또는 치료용 약학 조성물
출원번호: 10-2021-0048177
- 94. 세포 투과성 PGAM5 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2021-0053474
- 95. 세포 투과성 무기 피로인산 분해효소 1 융합단백질을 포함하는 운동신경 질환 예방 또는 치료용 약학 조성물
출원번호: 10-2021-0064532
- 96. 세포 투과성 PGK1 융합단백질을 포함하는 운동신경 질환 예방 또는 치료용 약학 조성물
출원번호: 10-2021-0088532
- 97. 발명의 명칭: 세포 투과성 CCT2 융합단백질을 포함하는 운동신경 질환 예방 또는 치료용 약학 조성물
출원번호: 10-2021-0099007
- 98. 세포 투과성 SH3GL3 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2021-0110664
- 99. 세포 투과성 STUB1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2021-0127020
- 100. 세포 투과성 PGK1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2022-0048277
- 101. 세포 투과성 무기 피로인산 분해효소 1 융합단백질을 포함하는 뇌허혈 치료용 약학 조성물
출원번호: 10-2022-0051236
교내활동
- 강릉원주대학교 공동실험실습관 관장
- 강릉원주대학교 실험실안전관리센터 센터장
교외활동
- 1. 생화학분자생물학회 운영위원회 위원
- 2. 생화학분자생물학회 홍보위원회 위원
- 3. 생화학분자생물학회 대위원
- 5. BMB Reports 관리위원회 위원
- 4. BMB Reports 편집위원회 편집위원